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VIVOTIF may help provide protection against typhoid fever for up to 5 years.1

Vivotif® can help provide protection against typhoid fever for up to 5 years Vivotif® can help provide protection against typhoid fever for up to 5 years
  • Not all recipients of VIVOTIF will be fully protected against typhoid fever1
  • The optimum booster schedule for VIVOTIF has not been determined1
  • It is recommended that a re-immunization dose consisting of 4 vaccine capsules taken on alternate days be given every 5 years under conditions of repeated or continued exposure to typhoid fever1

Sampling local cuisine can be one of the most enjoyable parts of traveling. But depending on your destination and culinary choices, you can be putting yourself at risk for typhoid fever.2

Typhoid fever is a potentially severe and life-threatening illness caused by a type of bacteria called Salmonella enterica serovar Typhi.2 It’s spread by contaminated food and water.2 Symptoms include headache, fever, chills, skin rash, and muscle aches.3.4 In severe cases, delirium, abdominal pain, or death may occur.4

Following food and water guidelines is important, but it may not completely protect you from getting the disease.5

Typhoid fever is commonly found
in many regions of the world,
including parts of
East and
Southeast Asia, the Caribbean,
Africa, and Central and South America.5

  • High prevalence = >100 cases per 100,000 people per year
  • Moderate prevalence = 10 to 100 cases per 100,000 people
    per year
https://www.cdc.gov/globalhealth/immunization/othervpds/typhoid.html
Typhoid fever is commonly found in many regions of the world, including parts of East and Southeast Asia, the Caribbean, Africa, and Central and South America

In addition to safe food and water precautions and proper hygiene,
the Centers for Disease Control and Prevention (CDC) recommends vaccination for people traveling to places where typhoid fever is common.6

It’s also important to know that the danger from typhoid fever doesn’t end when symptoms disappear.3 Even when symptoms seem to go away, you may still be carrying Salmonella Typhi and can pass it on to someone else.3

VIVOTIF is the only FDA-approved oral vaccine for typhoid fever.1

VIVOTIF is a prescription vaccine you take by mouth to help protect you from typhoid fever.1 VIVOTIF is for adults and children ages 6 and older.1

Immunization with VIVOTIF is not routinely recommended for people living in the United States.1 Not everyone who takes VIVOTIF will be fully protected against typhoid fever.1 While you travel, you should take care to ensure the food you eat and water you drink are safe.1

While typhoid fever can be treated with antibiotics, 71% of Salmonella Typhi infections are resistant to the most common antibiotic used to treat typhoid fever.7

VIVOTIF can help provide protection
just 1 week after your last dose.1

VIVOTIF is an oral vaccine.1

How to take VIVOTIF1:

  • One complete dosing schedule consists of 4 capsules
  • VIVOTIF is taken every other day for 7 days
    (see illustration below)
GET TEXT REMINDERS

To enroll in the TAKE 4 text reminder program, text "TRAVEL" to 1-833-207-3377 on the day of your first dose. You will receive a text every other day reminding you to take your next dose and to refrigerate the remaining capsules.*

*The information requested will be used by Emergent to send text message reminders. Message and data rates may apply. This is a recurring program that includes a number of messages over the course of 7 days. At any time during the program, patients may text "HELP" for assistance or "STOP" to discontinue receiving messages.

All 4 doses of VIVOTIF should be taken at least 1 week before traveling.1

All 4 doses of Vivotif® should be taken at least 1 week before traveling All 4 doses of Vivotif® should be taken at least 1 week before traveling

Swallow 1 capsule about 1 hour before a meal with a cold or lukewarm drink.1 It doesn’t matter what time you take your capsule, as long as it's at least 1 hour before a meal1:

  • Swallow capsule whole, don’t chew or break
  • Keep capsules refrigerated until you’re ready to take them

Select Safety Information

The most common side effects of VIVOTIF are abdominal pain, nausea, headache, fever, diarrhea, vomiting, and skin rash.1

GET TEXT REMINDERS

To enroll in the TAKE 4 text reminder program, text "TRAVEL" to 1-833-207-3377 on the day of your first dose. You will receive a text every other day reminding you to take your next dose and to refrigerate the remaining capsules.*

*The information requested will be used by Emergent to send text message reminders. Message and data rates may apply. This is a recurring program that includes a number of messages over the course of 7 days. At any time during the program, patients may text "HELP" for assistance or "STOP" to discontinue receiving messages.

ASK HOW VIVOTIF MAY HELP PROTECT YOU WHILE TRAVELING
TO TYPHOID FEVER-AFFECTED AREAS.

Important Facts About VIVOTIF (vee-voh-TEEF).
It is also known as Typhoid Vaccine, Live, Oral Ty21a.

What is VIVOTIF used for?

VIVOTIF is a prescription vaccine you take by mouth to help protect you from typhoid fever. Typhoid is a disease caused by a type of bacteria called Salmonella enterica serovar Typhi. VIVOTIF is for adults and children ages 6 and older.

Immunization with VIVOTIF is not routinely recommended for people living in the United States. However, VIVOTIF is recommended for people who are at a higher risk of getting typhoid. This includes:

  • People who travel to places where typhoid is more common
  • People who have close contact with someone who has had typhoid
  • People who work in laboratories who could have contact with typhoid

Not all people will be fully protected from typhoid following vaccination. While you travel, you should take care to ensure the food you eat and water you drink are safe.

It is unknown whether VIVOTIF protects from common source outbreaks of typhoid, disease following natural disasters, or in people attending rural summer camps.

VIVOTIF will not protect you from other kinds of Salmonella bacteria and will not treat typhoid fever if you have been infected.

Who should not take VIVOTIF?

Children under the age of 6 should not take VIVOTIF.

Do not use VIVOTIF if you are allergic to any of the ingredients in the vaccine or the
enteric-coated capsule.

Do not take VIVOTIF if you have an active fever or if your immune system is weakened by a disease or other medicines you take.

Warnings

Can I take VIVOTIF if I have a stomach or intestinal illness?

Tell your healthcare provider (HCP) if you have sudden stomach or intestinal illness. If you are vomiting or have diarrhea that will not stop, do not take VIVOTIF until the vomiting and diarrhea have stopped.

What should I know about how VIVOTIF works?

It is important to take VIVOTIF exactly as your HCP tells you. VIVOTIF may not fully protect you from typhoid if you miss a dose.

Not everyone that takes VIVOTIF will be fully protected against typhoid.

Can I take VIVOTIF if I take other medications?

Tell your HCP about all the prescription and over-the-counter medicines, vitamins, and herbal supplements you take.

Taking VIVOTIF with certain other medications may affect how VIVOTIF works and may cause
side effects.

What are the most common side effects of VIVOTIF?

The most common side effects of VIVOTIF are abdominal pain, nausea, headache, fever, diarrhea, vomiting, and skin rash. Only nausea was more common in people that took VIVOTIF compared with those who took a sugar pill.

These are not all the possible side effects of VIVOTIF. Talk to your healthcare provider about any side effects you experience.

You can report side effects to the FDA at 1-800-822-7967 or vaers.hhs.gov.

Learn more

This summary provides basic information about VIVOTIF, but it does not include all information known about this vaccine. Talk to your HCP or pharmacist about this information. Your HCP is the best person to help you decide if VIVOTIF is right for you.

VIV CON ISI 01/2021

For more information about VIVOTIF, please see full Prescribing Information.

References

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